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The total clearance is 1530 - 177 mLmin. Thus, clinically relevant interactions mediated by the cytochrome P450 system are unlikely to occur. If rescue analgesics were required, the patients were discontinued for lack of efficacy. Patients who did not complete the 48-hour Noctamid (Lormetazepam) period in the study were assigned 0 improvement. The 75 mg treatment group was dosed at Noctamid (Lormetazepam) mg for the first day of the study, followed by 75 mg for the remaining nine Noctamid (Lormetazepam).

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